Orlistat (Generic Alli™, Xenical®) is used with an individualized low-calorie, low-fat diet and exercise program to help people lose weight . Prescription orlistat is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease. Orlistat is also used after weight-loss to help people keep from gaining back that weight.

Orlistat is in a class of medications called lipase inhibitors. It works in the intestines by blocking absorption of some of the fat in foods eaten. This unabsorbed fat is then removed in stools from the body.